A mild pressor effect may be encountered in some patients. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. NOTE: Since Indigo Carmine is a dark blue solution, visual inspection for particulate matter prior to use may not be possible. The intravenous method is preferred because a 5 mL injection is sufficient. Sterile, nonpyrogenic. There are no data available describing the signs, symptoms or laboratory findings accompanying overdosage. FDA Safety Recalls, Uses. Copy the URL below and paste it into your RSS Reader application. A lesser dosage in infants, children and underweight patients will prevent skin coloration. Copyright © 2020 MIMS Pte Ltd. All rights reserved. It has a role as a food colouring, a histological dye and a two-colour indicator. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=56b8467d-c6c9-47a6-aaf4-eea94d937395, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. The dye is sprayed against the colon mucosa wall to identify any tissue which is indicating symptoms of IBD, Colorectal Cancer, Ulcerative Colitis amongst other diseases. A mild pressor effect may be encountered in some patients. INDIGO CARMINE 40 MG/5 ML SOLUTION FOR INJECTION, We comply with the HONcode standard for trustworthy health information -. Therapeutic uses, prescribing information and product availability may vary between countries. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Indigo Carmine 1% is issued (in a dilute state) for chromoendoscopy procedures with the aid of a spray catheter. INDIGO CARMINE- indigo carmine injection, solution  The intravenous method is preferred because a 5 mL injection is sufficient. Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body. Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. Indigo Carmine should be stored in the dark, away from direct light, preferably in the original package. The excretion of Indigo carmine … The biological half-life is 4 to 5 minutes following intravenous injection. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Updated Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body. For further information about unapproved drugs, click here. Copyright © 2020 MIMS. (current). Skin discolouration (high doses). Indigo carmine: Search drug information, interaction, images & medical diagnosis. Since precipitation of indigotindisulfonate sodium may occur, Indigo Carmine Solution must not be diluted prior to injection or injected with infusion assemblies which were used with other solutions. Report Adverse Indigo Carmine Dosage and Administration. Indigo Carmine solution is injected either by the intravenous or intramuscular route, and its appearance at the ureteral orifices is watched with the cystoscope in place. Labels, All Index PubMed, Indigo carmine, or 5,5′-indigodisulfonic acid sodium salt, is an organic salt derived from indigo by sulfonation, which renders the compound soluble in water. Indigo Carmine is contraindicated in patients who have previously experienced an adverse reaction following its use. It gives a deep blue solution when dissolved in water. No discernible symptoms of toxicity have been observed in mice with an intravenous dose of 200 mg/kg. The intravenous method is preferred because a 5 mL injection is sufficient. Get Label RSS Feed, Indigotindisulfonate sodium injection should be given to a pregnant woman only if clearly needed. It is not known whether this drug is excreted in human milk. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Its use is not known to lead to dependence or abuse. DOSAGE AND ADMINISTRATION. : Since Indigo Carmine is a dark blue solution, visual inspection for particulate matter prior to use may not be possible. Store at 20º to 25º C (68º to 77º F); excursions permitted to 15º to 30º C (59º to 86º F) (See USP Controlled Room Temperature). Indigo Carmine solution is injected either by the intravenous or intramuscular route, and its appearance at the ureteral orifices is watched with the cystoscope in place. To ensure that the withdrawn solution contains no particulates, 5 micron filter straws/filter needles must be used when withdrawing contents of ampules. pH adjusted, when necessary, with Citric Acid and/or Sodium Citrate. Nausea, vomiting, hypertension, bradycardia and occasionally, rash, pruritus and bronchoconstriction. Taking a single dose of expired Indigo Carmine is unlikely to produce an adverse event. & Articles, All Appearance time and elimination are delayed following intramuscular injection. Its use is not known to lead to dependence or abuse. It has the E number E132. A lesser dosage in infants, children and underweight patients will prevent skin coloration. All rights reserved. It is also not known whether indigotindisulfonate sodium injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. The biological half-life is 4 to 5 minutes following intravenous injection. Because many drugs are excreted in human milk, caution should be exercised when Indigo Carmine is administered to a nursing woman. Indigo carmine is also a redox indicator, turning yellow upon reduction.Another use is as a dissolved ozone indicator through the conversion to isatin-5-sulfonic acid. After intravenous administration the LD50 was established at 300 mg/kg in mice. this version. An occasional idiosyncratic drug reaction may occur. Elimination of the dye begins soon after injection, appearing in the urine within 10 minutes in average cases. Disclaimer: This information is independently developed by MIMS based on Indigo carmine from various references and is provided for your reference only. Indigo carmine is indicated in following settings:. Animal Reproduction studies have not been conducted with indigotindisulfonate sodium injection. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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